The Best Co-Enzyme Q10 Supplements


Many co-enzyme Q10 (coQ10) supplements are available, but some are better than others. I have reviewed some of the best ubiquinone and ubiquinol supplements below, and explained why I believe these products are worth investing in.

What is Co-enzyme Q10?

Co-enzyme Q10 (abbreviated to CoQ10) is a powerful antioxidant that is vital for energy production in cells. The amount of CoQ10 you make declines with age and depleted amounts is associated with premature cell ageing and fatigue. Known as nature’s spark plug, you may benefit from taking a co-enzyme Q10 supplement if you have high blood pressure, feel lacking in energy, or are taking a statin drug to lower a raised cholesterol or lower your future risk of heart disease.

Statin drugs work by switching off cholesterol production in the liver. This action also switches off CoQ10 production, and can halve circulating levels of this important cell energy-producing substance within 2 to 4 weeks. This may contribute to the muscle-related side effects associated with statin medication.  

Vitamin D is also produced from a cholesterol-derived building-block, and a low-level of vitamin D may be involved, too.

Which is the best dose of co-enzyme Q10?

Energized

Co-enzyme Q10 supplements come in three main forms:

  • Ubiquinone must be converted into another form, ubiquinol, in the body before it is used. This form is widely available and offers best value for money for younger people.
  • Ubiquinol is the reduced ‘body-ready’ form, also known as Co-enzyme QH. This form is the most effective for older people, and those taking a statin drug.
  • Mitoquinol is a positively-charged form which easily penetrates into the cells’ power houses (mitochondria) so that a lower dose is needed. This new version is more expensive but may suit you if you have not achieved optimal results with other versions, or if you have mitochondrial dysfunction which is associated with fibromyalgia and chronic fatigue.

The optimum dose of co-enzyme Q10, and the best form, depends on your age and why you wish to take it. If you are in good general health, my suggested doses are:

  • 30mg ubiquinone if you are under 30 years of age.
  • 60mg ubiquinone if you are aged 30 to 40 years.
  • 100mg ubiquinone if you are aged 40 to 50 years.
  • 100mg in the ubiquinol form if you are aged 50 plus.

If you have high blood pressure, are taking a statin or have reduced fertility or heart problems, a dose of 200mg ubiquinone or 100mg ubiquinol may be better. Higher doses of ubiquinone and ubiquinol can be taken, but I believe these are best used under the advice of a medical nutritionist to supervise any underlying health problems.

Mitoquinol is taken at a typical dose of two 5mg capsules each morning. It may be suitable for people with mitochondrial dysfunction who feel they have not achieved optimum benefit from taking ubiquinone or ubiquinol alone.

NB Check with your doctor if you have an underlying health problem or are taking any prescribed medicines.

Which co-enzyme Q10 supplements are best?

My advice is to select a product made to a pharmaceutical standard known as GMP (Good Manufacturing Practice). This quality control ensures that each capsule supplies what it says on the label. As co-enzyme Q10 is fat soluble, capsules supplying ubiquinone or ubiquinol in an oil-base will aid maximum absorption.

Doctor’s Best Ubiquinol is made to GMP standards. Each softgel supplies 100mg.

The suggested dose is 1 a day

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Solgar CoQ-10 Softgels are made to GMP standards, with each softgel capsule providing 200mg co-enzyme Q10 as ubiquinone.

The suggested dose is 1 capsule per day.

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Pharma Nord Bio-Quinone Q10 Gold Capsules are produced to a Danish pharmaceutical standard that is equivalent to GMP.

Each capsule supplies 100mg co-enzyme Q10 in the ubiquinone form. The suggested dose is 1 to 4 capsules per day.

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Sometimes also available on Amazon.com

MitoQ provides 5mg mitoquinol per capsule.

The suggested dose is 2 capsules each morning.

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MitoQ Anti-Ageing Moisturising Serum

Manufacturers are increasingly adding co-enzyme Q10 to skincare products to provide an incredible anti-ageing boost. MitoQ serum contains mitoquinol, a form of CoQ10 that rapidly penetrates into the mitochondrial powerhouses of cells within the dermis, where it optimises oxygen processing.  

As a powerful antioxidant, it also helps to protect skin from the damaging effects of pollution, and promotes repair and rejuvenation.

 

MitoQ Serum offers a rejuvenating boost for skin.

A little goes a long way and rapidly sinks in, making it lovely to use. I’m now on my second one!

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Have you taken co-enzyme Q10 supplements? If so, what for? Did you find them helpful? 

Image credit: funnyangel/shutterstock




About Dr Sarah Brewer

Dr Sarah Brewer qualified from Cambridge University with degrees in Natural Sciences, Medicine and Surgery. After working in general practice, she gained a master's degree in nutritional medicine from the University of Surrey. Sarah is a licensed Medical Doctor, a Registered Nutritionist and a Registered Nutritional Therapist. She is an award winning author of over 60 popular self-help books and set up this site to showcase all that is good in the world of self-help.


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25 thoughts on “The Best Co-Enzyme Q10 Supplements

  • Snezhana

    Thank you Dr. Brewer, and one more question: I have headaches and I’m sleepy these days, if it’s Coq10 induced, should I stop taking the supplement? By the way, I have 12 years old twins myself, and this time one healthy baby will do. 😉

    • Dr Sarah Brewer Post author

      Hi Snezhana, CoQ10 doesn’t usually causeside effects. Only occasional and transient, mild nausea have been reported even at high doses. If you think it is affecting you, then obviously stop. It’s a good idea to be checked for other possible causes such as iron deficiency anaemia, low thyroid function, diabetes – or could you be pregnant already? Best wishes, Sarah B

  • Snezhana Bajraktarova

    Dear Dr. Brewer,
    I am 42 years old and I want to do everything I can to increase the egg quality, because my spouse and I want to have another child. I started taking 30mg/day CoQ10 a week ago and for last two days I’ve been on 100mg/day. I wanted to switch to ubiquinol, but I’ve read some warnings that people with low blood pressure should not take co-enzyme Q10 supplements, which was very disappointing for me, since my blood pressure is often low, 110/70, sometimes lower.
    I’m not sure how to proceed, so I need your opinion and advice.
    Thank you in advance,
    Snezhana

    • Dr Sarah Brewer Post author

      Hi Snezhana, CoQ10 can definitely improve egg (and sperm) quality as I’ve written about in my post on CoQ10 here. Doses of CoQ10 used to lower blood pressure are generally high – around 400mg to 600mg and you are unlikely to run into problems from taking the ubiquinol form at a dose of around 100mg, but if you develop symptoms of hypotension such as feeling dizzy then do stop and seek advice from your doctor. Fingers crossed for you – I had twins at the age of 42 and firmly believe that coQ10 and pregnancy multivitamins played a role. Best wishes, Sarah B

  • Clare

    Thanks Sarah, I hadn’t seen your other piece about it’s links to fertility. There are twins in both our families so heres hoping. I am taking a preconception vitamin also so will purchase some ubiquinol and keep our fingers crossed. Thanks again..Clare

  • Clare

    Hi Sarah, I’m 38 and looking to take Co Q10 to help with fertility, I’ve read that it can improve the quality of your eggs? I just lost a baby to T21 and my partner would like to do what we can to aid the process going forward. How much and which form would you recommend taking in my situation. My partner is the same age, works out every day and is often very tired so I think could benefit from it too? Thank you for your time, Kind Regards, Clare

    • Dr Sarah Brewer Post author

      Hi Clare, Sorry to hear about your experience. Yes, CoQ10 can help boost both male and female fertility, as I’ve written about on my Nutritional Medicine blog here. The best form is ubiquinol, and the usual dose is 100mg to 300mg per day. It’s also a good idea to take a multivitamin and mienral supplement designed for pregnancy, as nutrients such as folate, B vitamins and zinc also play a role. Best wishes, Sarah B

  • Jonny

    Which CoQ10 do you take, seems that one might as well just take MitoQ, and forget the rest, as it appears superior/next generation? Have you looked at John O’Neills CoQ10 https://advancedq10.com/ It is a powdered version – he makes some interesting comments about oil based soft gel CoQ10 – although not sure how qualified they are – while they do exhibit increased blood plasma levels of CoQ10, they also showed high urine excretion rates of CoQ10. He also suggests that adding oil oxidises Q10 so it’s missing the massive molecular structure of active hydrogen that’s found in a quality coenzme q10. I am new to coQ10, so would be great to hear your thoughts on which is best, regardless of expense. Thanks for a great article.

    • Dr Sarah Brewer Post author

      Hi Jonny, I take 100mg ubiquinol in an oil base. Adding oil does not oxidise ubiquinol as it is produced in an oxygen-free environment – a process for which Kaneka has the patent. All the evidence I have seen suggests this is the best form for over-50s. Under this age you could go for the ubiquinone form which tends to be cheaper. Best wishes, Sarah B

  • James C

    Well I have to admit that I stumbled on this page, I am certainly glad I did.
    I’m constantly amazed by the vast market in health supplements. I had never heard of CoQ10 before. I am often rather sceptical about most of the advertised claims of these products. How ever when I see something being endorsed by such a qualified person as yourself Dr Sarah, then I do sit up and take notice.
    I am a slightly flagging sixty year old, so I will definitely try them and follow your advice.
    Thanks for giving it.

  • Monica Simm

    Dear Dr Brewer,
    I’m a 56 yr old woman on 75mcg Levothyroxine daily. I wish to improve my energy levels and general all round health. Can I take Co-Enzyme 10 supplements together with Thyroxine?
    Thanks,
    Monica.

    • Dr Sarah Brewer Post author

      Hi Monica, CoQ10 is often low in people with thyroid conditions and you may find it helps to improve thyroid function, although this is not guaranteed.The medications that can interact with coQ10 (usually resulting in lower CoQ10 levels) are listed here and do not include levothyroxine. Do read the information on the patient informatin leaflet that comes with your medicine, and cehck with your doctor or pharmacist, too. Best wishes, Sarah B

    • Dr Sarah Brewer Post author

      Hi Monica, CoQ10 is often low in people with thyroid conditions and you may find it helps to improve thyroid function, although this is not guaranteed.The medications that can interact with coQ10 (usually resulting in lower CoQ10 levels) are listed here and do not include levothyroxine. Do read the information on the patient information leaflet that comes with your medicine, and cehck with your doctor or pharmacist, too. Best wishes, Sarah B

  • Dave

    Dr. Brewer,
    Very helpful information. Ive been using a Qunol Ultra Natural COQ10 supplement though I dont know whether its a Ubiquinone or Ubiquinol I hadnt known there were multiple forms of the supplement.
    Ive taking the supplement for a few years as I had been told it was a good antioxidant. Although, I have noticed that when I don’t take the CoQ10 supplement for a while, I do start feeling a lack of energy.

    • admin

      I notice the same if I stop taking it. You look young in your Gravitar so you probably don’t need Ubiquinol yet but if you notice your energy levels dipping, trying switching to ubiquinol – the ones you are taking are ubiquinone although in an oil base for optimal absorption.

  • Sangeeta

    Thanks doctor for providing the list of best capsules supplying ubiquinone or ubiquinol. Actually I was thinking of taking CoQ10 a year back as I used to feel lack of energy on me, may be due to heavy work load and lack of sleep. But I was not not sure about the best supplement available in market. neither I went to any doctor because of work pressure again.
    But now, the best supplements list is here and I can get one for me.

    • admin

      Glad it was helpful. You should notice an improvement in energy levels within a couple of weeks. ONe of my favourite supplements!

  • Raymond

    Hi doctor,

    I first heard about coq10 2 years ago from the book called the cholesterol myth and how it is vital to our health. Its strange that other doctors still prescribe statin when it has side effects.

    Reading your article has given your readers an in depth information about the coq10. I never knew about ubiquinol or mitoquinol and the other one. I usually just buy the dr. Best coq10 and take it
    I dont have high cholesterol but I am always finding ways to be healthy and if ever i need to take coq10 again. I will get the 60mg uniquinone. Cheers!

    • admin

      You don’t have to have a high cholesterol to benefit from CoQ10 as it is so important for energy production in cells. I notice loss of oomph within a few days if I stop taking it!

  • ches

    There are so many supplements out there, it is a minefield to pick the best one. With CoQ10 the array to choose from is really confusing for the public.
    I am so pleased to see a medical doctor also using naturopathic treatments and giving advice about these supplements. I can remember reading that the four best nutrients, especially for cardiovascular were: D-ribose, magnesium, CoQ10 and L-carnitine.
    Magnesium is my choice, if I only had one to choose and that’s because it has changed my life. I have yet to try CoQ10 purely because I didn’t know which one to go for. Now I do! Ches

    • admin

      HI Ches, I take both magensium and CoQ10 every day as they both do something different and complement each other too. Both have beneficial effects on blood pressure, and people with higher magnesium levels tend to live longer than those with lower levels. WIn win!

  • Tim

    Hi Sarah,
    An excellent post on Co-Q10 and I learned some good information from it. I have been taking Co-Q10 for about 2 years now. I have taken both the Ubiquinone and Ubiquinol form, but I hadn’t heard of Mitoquinol. At the moment I’m taking a form called Ubidecarenone. I’m not sure how that compares to the other forms.
    Since this targets directly the mitochondria, boosting their ATP production, I wonder if this has value as part of cancer therapy since cancer seems to be largely a metabolic disease. I just had a look and found some papers suggesting that this might be the case. There’s some great information on your website. Thanks!

  • M Hovgaard

    Dear Dr. Brewer
    Thank you for posting a review of Bio-Quinone Active CoQ10 Gold. Our pricing and availability in the US has changed. Our products are available at healthfood stores, through healthcare practitioners and online at http://www.pharmanord.com. The 150 softgel pack retails for $109.95 (60 softgels are available for $53.95).